Fusco BM, Marabini S, Maggi CA, et al: Preventative effect of repeated nasal applications of capsaicin in cluster headache. ![]() Van Rijswijk JB, Boeke EL, Keizer JM, et al: Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: A double-blind randomized application regimen study. Ellis CN, Berberian B, Sulica VI, et al: A double-blind evaluation of topical capsaicin in pruritic psoriasis. Theophylline: Concurrent administration with capsaicin may increase absorption.Īntihypertensives: Capsaicin may affect the action of antihypertensive medications. Sedatives: Capsaicin may increase sedation. HERB-DRUG INTERACTIONS: Capsaicin preparations may interact with the following:ĪCE inhibitors: Capsaicin can increase the incidence of cough associated with ACE inhibitors. Interestingly, it demonstrated chemopreventive properties, but this has not been verified in human studies.ĪDVERSE REACTIONS: Common (topical): Burning, urticaria, contact dermatitis. Originally thought by some to be a carcinogen,Ĭapsaicin was shown to be safe in animal studies. Its utility for arthritic pain remains inconclusive.Ī review of studies of capsaicin for neuropathic pain associated with HIV, diabetes, mastectomy, and postherpetic neuralgia concluded that available data are too limited to enable full assessment of its benefits, and that additional well-designed clinical trials are required. Studies support the benefits of topical capsaicin for psoriasis, and of intranasal application for rhinitis and cluster headaches.ĭata also suggest that capsaicin cream can effectively control postsurgical pain in cancer patients. Capsaicin is currently available in capsule form and as an ingredient in topical creams.Ĭapsaicin is thought to reduce pain sensation by temporarily depleting a neurotransmitter, substance P, which relays pain signals to the brain. ![]() It has been used in traditional medical systems as a remedy for digestive and circulatory problems, poor appetite, and to relieve muscle and arthritic pain. Capsicum or cayenne pepper, a shrub prevalent in many tropical and subtropical climates, is an important ingredient of many cuisines around the world. From the fruit of capsicum, is used to relieve pain, to improve circulation, to treat cluster headaches and psoriasis, and for weight loss.
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